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Evidence-Based Medicine  

Evidence-Based Medicine
Last Updated: Sep 20, 2014 URL: Print Guide RSS Updates
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Levels of Evidence

Systematic Reviews

  • Cochrane Library
    The Cochrane Library is an electronic publication designed to supply high quality evidence to inform people providing and receiving care, and those responsible for research, teaching, funding and administration at all levels. UH users may click on the ENTER button to access full text without logging in with username and password.
  • DARE (Database of Abstracts of Reviews of Effects)
    DARE contains 15,000 abstracts of systematic reviews including over 6,000 quality assessed reviews and details of all Cochrane reviews and protocols. The database focuses on the effects of interventions used in health and social care. From UK's National Institute for Health Research

Databases- Critically Appraised Topics

The following databases are searchable by subject and includes critically appraised topics.

  • National Guideline Clearinghouse
    NGC is a public resource for evidence-based clinical practice guidelines. Gathered by the UHDHHS Agency for Healthcare Research and Quality (AHRQ).
  • PubMed Health  
    up-to-date information on diseases, conditions, drugs, treatment options, and healthy living, with a special focus on comparative effectiveness research from institutions around the world. Click on "comparative effectiveness" links for EBM type reviews.

Databases - Critically Appraised Individual Articles

  • Evidence Based Medicine
    Journal from BMJ collection of journals. Critiques individual published studies from other journals.
  • Evidence Based Mental Health
    Journal from BMJ collection of journals. Critiques individual published studies from other journals.
  • ACP Journal Club
    Critiques of the published research articles and systematic reviews. Publication of the American College of Physicians.

Databases - Research Literature

Search PubMed MEDLINE for Randomized Controlled Trials (RCTs), Cohort Studies and Case-Controlled Studies

Click on link to PubMed from the Library and click on "Clinical Queries" under "PubMed Tools" (middle column) OR go to "Advanced Search" and under "More Resources" at the end of the page, click on "Clinical Queries."

May search by categories such as Therapy, Diagnosis, and Prognosis and limit to broad or narrow.  Narrow produces the best evidence.

Please ask librarians for assistance:  692-0810 or

  • PubMed MEDLINE
  • TRIP Database
    The TRIP Database is a clinical search engine designed to allow clinicians to quickly find answers to their clinical questions using the best available evidence. For access to the full text, log in to the database via this link. For the most part the publisher's icons will link to the full-text of our subscribed resources. Another way to get to the full text of the articles is that when you link to a PubMed citation login to your MY NCBI account and the UH Manoa icons will appear again.
  • SUMSearch
    SUMSearch simultaneously searches for original studies, systematic reviews, and practice guidelines from multiple sources. Results from PubMed, Dare, and NGC are merged and sorted. As SUMSearch executes live searches of external websites in response to your query, SUMSearch is always up-to-date. Click on the "PMID" link to citations for access to full-text HSL library sub..may require logging into your MyNCBI account to see holdings icons
  • Mobile PubMed Related Databases from NLM
    This is a link to a trio of databases from the National Library of Medicine. They all contain besides the usual PubMed Abstracts a "TBL" (The Bottom Line) summary. Note that the first database gives you a PICO interface.

Background Information/Expert Opinion

Includes databases such as FirstConsult and eMedicine.

  • FirstConsult
    Includes 700 topic monographs with updated diagnositic, treatment recommendations, questions to ask, and references.
  • Medscape
    Formerly known as eMedicine. Free but must register.
  • CRD Databases
    From the UK's National Institute for Health Research Centre for Reviews and Dissemination. Includes DARE (Database of Abstracts of Reviews of Effects), NHS EED (Economic Evaluation Database), HTA (Health Technology Assessment) Database.

Rational clinical Examination Series from JAMA

Articles from this series cannot be easily searched in PubMed as the words "Rational Clinical Examination" are not indexed.  It is best to use Google Scholar and do the following search: 

"rational clinical examination" jama

Quotes are used to force Google Scholar to search the words as a phrase.

Also be sure to search Google Scholar via the Library's link for access to the full text articles.  It is not perfect but most of the series can be identified that way.


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